The protein encoded by this gene belongs to the flavin monoamine oxidase family it is a enzyme located in the mitochondrial outer membrane it catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. Monoamine oxidase a, maoa (mim 309850), contains 15 exons and is located on chromosome xp1123 during embryonic development maoa is the main catabolic enzyme for degradation of both dopamine and norepinephrine  suggesting a possible impact on adult behavior. Et al,2012rietveld et al,2013) although twin studies are an important rst step in establishing the role of genes for a particular behavior, they do not identify the speci c genes involved. Analysis of data from several studies indicates that the strongest link between genetic variation and aggression comes from monoamine oxidase a (maoa) a gene encoding an enzyme responsible for catabolising amine neurotransmitters such as dopamine, serotonin and noradrenaline. Boys who carry a particular variation of the gene monoamine oxidase a (maoa), sometimes called the warrior gene, are more likely not only to join gangs but also to be among the most violent.
Firstly, this essay will aim to introduce and explain the genetic factors, how the monoamine theory of depression was developed and why in the recent years depression is no longer seen as a disorder of the monoamine transmitters. Monoamine oxidase a (maoa) is a mitochondrial enzyme, which degrades monoamine neurotransmitters and dietary amines and produces h2o2monoamine oxidase a (maoa) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis. Monoamine oxidase a gene (maoa) has earned the nickname “warrior gene” because it has been linked to aggression in observational and survey-based studies however, no controlled experimental studies have tested whether the warrior gene actually drives behavioral manifestations of these.
Manuck sb, flory jd, ferrell re, mann jj, muldoon mf: a regulatory polymorphism of the monoamine oxidase-a gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. The low activity form of the gene that encodes monoamine oxidase a (maoa-l) are more likely to show aggression when provoked or challenged [19, 20] in psychiatric patients the low activity maoa and early life. Monoamine oxidase b, also known as maob, is a protein which in humans is encoded by the maob gene the protein encoded by this gene belongs to the flavin monoamine oxidase family it is an enzyme located in the mitochondrial outer membrane. Monoamine oxidase (mao) reaction phenotyping is a non-cyp mediated metabolism assay within our portfolio of in vitro adme screening services cyprotex deliver consistent, high quality data with the flexibility to adapt protocols based on specific customer requirements.
In italy, a judge reduced the sentence of a defendant by 1 year in response to evidence for a genetic predisposition to violence the best characterized of these genetic differences, those in the monoamine oxidase a (maoa), were cited as especially relevant. The gene that encodes monoamine oxidase a (maoa-l) will be more likely to react with aggression to challenge (12) recent work in behavioral genetics has stressed the importance of inter-actions between genetic predispositions and environmental con-tingencies (13. Monoamine oxidase inhibitors (maois, maoi) is a class of antidepressants they are infrequently prescribed because of concerns about interactions with particular foods and several drug interactions side effects, drug interactions, storage, dosage, and pregnancy safety information should be reviewed prior to taking any medication.
Monoamine oxidase a (maoa) is a monoamine-metabolizing enzyme the gene that encodes maoa is located on the x chromosome, and a polymorphism located within the eighth exon (941tg) is associated with low (941t) or high (941g) maoa activity ( hotamisligil & breakefield, 1991 . Analysis of conserved active site residues in monoamine oxidase a and b and their three-dimensional molecular modeling received for publication, november 14, 2001, and in revised form, january 30, 2002. Abstract functional allelic variation in the transcriptional control region of the serotonin transporter and monoamine oxidase a genes has been associated with anxiety- and aggression-related behavior in humans and, more recently, in nonhuman primates.
Gene for monoamine oxidase type a assigned to the human x chromosome j neurosci 19811:166-75 sims kb, de la chapelle a, norio r, sankila em, hsu yp, rinehart wb, et al monoamine oxidase deficiency in males with an x chromosome deletion. The monoamine oxidase a (maoa) gene is an outer membrane mitochondrial enzyme that breaks down monoamines such as serotonin, noradrenalin and dopamine. “monoamine oxidase a, also known as mao-a, is an enzyme that in humans is encoded by the maoa gene this gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Monoamine oxidase a deficiency: introduction monoamine oxidase a deficiency: a very rare syndrome characterized mainly low levels of monoamine oxidase a (maoa) activity low levels of maoa have been implicated with increased behavioral problems such as violence and impulsiveness.
Imagine a global collaborative knowledge base for original thoughts search thousands of articles and collaborate with scientists around the globe gene-gene interaction between the monoamine oxidase a gene and solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2 gene in anorexia nervosa (restrictive subtype. The human monoamine oxidase (mao) b plays a major role in the degradation of biogenic and dietary amines such as phenylethylamine, benzylamine, dopamine, and tyramine we previously showed that the −246/−99 mao b promoter region exhibited the highest activity and contained two clusters of overlapping sp1 sites, a caccc element and a tata box. Monoamine oxidases (mao) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin they are found bound to the outer membrane of mitochondria in most cell types in the body two subtypes of monoamine oxidase have been identified: mao-a and mao-b.